A Structural Feature of Human Immunoglobulin Light Chains
نویسندگان
چکیده
منابع مشابه
A structural feature of human immunoglobulin light chains. Two compact domains connected by a small switch region.
A lambda immunoglobulin light chain from a myeloma patient, normal light chains, and fragments one-half the size of these chains have been examined by chemical and physical methods. Fragments produced from the X chain with trypsin, pepsin, and papain, and free urinary fragments of this chain were isolated. Characterization of the various fragments of the X chain by amino acid analyses, peptide ...
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1. The light chains of human immunoglobulin were allowed to dimerize in vitro on removal of the dispersing agents acetic acid or urea. 2. On electrophoresis in polyacrylamide gel at pH8.8 the dimers yielded up to nine regularly spaced bands. This approximates to the number of electrophoretic components known to occur among the monomers. 3. Single electrophoretic components of the dimers were is...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1972
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)45616-0